TChipD1-1-5m-Z100 Basic Tissue Chip

NBT Original

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THIS IS A SINGLE CHANNEL DEVICE FOR APPLICATIONS FOR STARTERS OF TISSUE/ORGAN-ON-A-CHIP APPLICATIONS. THE MIDDLE LARGER AREA IS FOR TISSUE CULTURING. SYNTHETIC OR PRIMARY TISSUE SLICES ARE ALSO APPLICABLE TO BE CULTURED WHEN YOU CHOOSE UNBONDED CHIP OPTION.

BONDING TO GLASS OR ANOTHER PDMS LAYER OR UNBONDED PURCHASE IS OPTIONS ARE AVAILABLE.

ALL PRICES ARE WITHOUT VAT AND THE SHIPPING COSTS CAN BE SEEN AT THE SHOPPING CART AFTER PROVIDING SHIPPING ADDRESS.

 

 


 Microfluidics is beneficial for saving reagent consumption. Tissue or organ-on-a-chip is a type of application of microfluidics technology for mimicking organism tissue sections for mainly pharmaceutical testing applications. Tissue-on-chips are engineered microsystems to be worked as organs like skin, liver or brain. Metabolism, physical structure and functional modeling is the primary issue.

 Ultimately, this new technology aims to make pharmaceutical development, especially toxicology and efficacy screening, more reliable, because the tissue chips may provide researchers with insights into predicting more accurately how effective potential pharmaceuticals would be in humans.

 It is also very promising for 3Rs (Reduction, Refinement, Replacement) for animal use in research experiments.

 It is not only for representing human organ/tissues during the pharmaceutical development process but also various areas of research given below

--- Life Sciences: molecular biology analysis of tissues slices, 3d culture of primary tissues, cell invasion and motility analysis in tissue-like structures
--- Pharmaceutical Sciences: Pharmaceutical toxicology and efficacy studies, understanding the metabolism of pharmaceuticals, pharmaceutical permeability between different tissue interactions
--- Biotechnology: complete organism mimicking
--- Diagnostic tech: metabolized pharmaceutical diagnosis
--- Others: testing of new molecules of  cosmetics products, food additives, agrochemicals, etc on emulating tissue chips



 DATASHEET

Specification Info
Number of devices per chip 9 devices
Material PDMS bonded on microscopy glass. Please also check the "Our Trip to PDMS Chips" blog post.
Bonding technique Oxygen plasma treatment
XY Size of total chip 25x73 mm2 of the chip on 26x76 mm2 of std microscopy glass
Z Height of PDMS chip 3.0 - 4.0 mm
XY Size of the active site X width is 5.0 mm and Y length is 5.0 mm.
Z Height of microchannels 100 micrometer
Microchannel surface area 25 mm2 of active site and 57.5 mm2 for complete device
Microchannel volume 5,76 uL per device excluding ports
Ports on top/edge on Top
Number of ports 18 ports per device
Pitch btw ports and edge-to-port 3 mm and 3.5 mm
Size / Shape of ports 2 mm / Circle
Suitable connector outer diameter 2.0 - 2.5 mm
microChannel geometry Rectangular
The layout of Active ports small-layout-bw-tcd1-1
... ...

 


 REQUIREMENT

Additional Requirements Suggestions
Pumping/Actuation Flow and mixing of the liquids inside microchannels require low-pulsation flow.
Some high-quality syringe pumps and pressure pumps work well.
Peristaltic and piezoelectric pumps may also be suitable but mind the possible relatively high pulsation.
Fittings All fittings in ufluidic.com are suitable with this chip. Any other connectors compatible with pitch and port size are also applicable. Reactive compatibility of the fittings is also important to be considered.
Chemicals It depends on the application of the researcher.
Visualization Epi-Fluorescent Microscopy is widely used together with microfluidic chips.
Other analysis techniques should be determined by user researchers for the experiments where optical changes inside chips do not occur.

 


 LITERATURE

Application examples from literature

These are some highly sited articles from literature. The chip designs are not identical but working is same in principle.

Ronaldso-Bouchard and Vunjak-Novakovic, 2018
 Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in DrugDevelopment
10.1016/j.stem.2018.02.011
Ahadian et.al., 2017
 Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies
10.1002/adhm.201700506
Perez-Rodriguez et.al., 2018
 3D Cell Migration Studies for Chemotaxis on Microfluidic-Based Chips: A Comparison between Cardiac and Dermal Fibroblasts
10.3390/bioengineering5020045
Li et.al., 2018
 Advances in tumor-endothelial cells co-culture and interaction on microfluidics
10.1016/j.jpha.2018.07.005
Song et.al., 2018
 Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases
10.3390/ijms19040935
Sleeboom et.al., 2018
 Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
10.1242/dmm.033100
 

 

 

 

Kullanım Kılavuzu Yakında eklenecektir
Akış Testi - Multimedya
Örnek Uygulama - Multimedya Yakında eklenecektir.

 


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